"Baxter R","Martin JL","","","","","","","","","Structure of the Mr 140,000 growth hormone-dependant insulin-like growth factor binding protein complex: Determination by reconstitution and affinity labelling.","Proc Natl Acad Sci","86","6898-6902","1989","BP","igf","method","","","detailed strutural analysis of IGF-BP 150. GH dependant. Alpha, beta and gamma (IGF) subunits.","etal_off","research","copy_on"
"Dawson TP","Gandhi R","LeHir M","Kaissling B","","","","","","","Ecto-5‘-Nucleotidase: Localization in the Rat Kidney by Light Microscopic Histochemical and Immunohistochemical Methods.","J Histochem Cytochem","37","39–47","1989","renal","","","","","Possible mechs of Glom/Tubeule feedback.","etal_off","research","copy_on"
"Wilkins J","D'Ercole AJ","","","","","","","","","Affinity labelled plasma somatomedin-C/insulin like growth factor I binding protein. Evidence of growth hormone dependence and subunit structure.","J Clin Invest","75","1350-1358","1985","igf","method","","","","Original work on DSS crosslinking and PAGE.","etal_off","research","copy_on"
"Adams SO","Kapadia M","Mills B","Daughaday WH","","","","","","","Release of insulin-like growth factors and binding protein activity into serum-free medium of cultured human fibroblasts.","Endocrinol","115","520-526","1984","igf","method","","","","Acid/EtOH & gel extraction. Contradicting previous paper, believes that acid strip NOT enough. Confusing HPLC results. Binding protein assay with DSS.","etal_off","research","copy_on"
"Unterman TG","Patel K","Kumar Mahathre V","Rajamohan G","","","","","","","Regulation of Low Molecular Weight Insulin-Like Growth Factor Binding Proteins in Experimental Diabetes Mellitus.","Endocrinol 1990b","126(5)","2614","1990","igf","bp","","","","BP assay with Charcoal, ref and method. Problem with stripping off IGF. Good range of methodologies, ligand blots, DSS affinity labelling, Neutral gel analysis.","etal_off","research","copy_on"
"Wang JF","Hampton B","Mehleman T","Burgess WH","Rechler M","","","","","","Isolation of a Biologically active fragment from the carboxy terminus of the fetal rat binding protein for insulin-like growth factors.","Biochem Biophys Res Comms","157(2)","718-726","1988","bp","method","","","","Methods, BP ligand assay c charcoal. CM 2-3 litres. Dialysis vs 0.1M AA. DSS X-link method. Possible that 14k fragment would be difficult to separate off on column.","etal_off","research","copy_on"
"Lamson G","Oh Y","Pham H","Giudice LC","Rosenfeld RG","","","","","","Expression of two insulin like growth factor binding proteins in a Human endometrial cancer cell line: Structural, Immunological and Genetic characterization.","J Clin Endo Metab","69(4)","852","1989","bp","igf","","","","Good coverage of the FIVE BPs & actions. Differential glycosylation ->apparent diff MWs. Amniotic fluid-hBP25- inhibits mitogenic action ofIGF. ?Paracine action of BP modulating IGF action. Methods - Westernblots.","etal_off","review","copy_off"
"Dawson TP","Wyllie FS","Wynford-Thomas D","","","","","","","","In Vitro Responsiveness to Serum Growth Factors is inversely related to in vivo malignancy in human thyroid epithelial cells.","Br J Cancer","63","897–900","1991","GFs","thyroid","","","","A paradox....?","etal_off","research","copy_on"
"Hossenlopp P","Seurin D","Segovia-Quinson B","Hardouin S","Binoux M","","","","","","Analysis of Serum insulin like growth factor binding proteins using Western Blotting: Use of the method for titration of the Binding Proteins and competative binding studies.","Anal Biochem","154","138-143","1986","method","bp","","","","Original Ligand blotting method as used by Zapf.","etal_off","research","copy_off"
"Blum WF","Jenne EW","Reppin F","Keitzzman K","Ranke MB","Bierich JR","","","","","Insulin-like growth factor I (IGF-I)- binding protein complex is a better mitogen than free IGF-I","Endocrinol","125","766-772","1989","igf","rate","","","","Secretion rate of IGF - BHK 7.5/HSF 24 mg/24hrs/million cells. IGF ata low continuous level promotes mitogenesis. Kd of receptor and BP similar therefore supplies at just right rate. Good description of receptor internalization. Equilibrium explains why","etal_off","research","copy_off"
"Zapf J","Schmid Ch","Guler HP","","","","","","","","Regulation of binding proteins for insulin-like growth factors (IGF) in humans. Increased expression of IGF binding protein 2 during IGF 1 treatment of healthy adults and patients with extrapancreatic tumour.","J Clin Invest","86","952-961","1990","bp","igf","","","","Hossenlopp's ligand blotting method described. Summary of normal serum binding proteins. Hypothesis on regulation of insulin like effects of IGF by localization effects of BPs intravascularly.","etal_off","research","copy_off"
"Unterman TG","Oehler DT","Gotway MB","Harris PW","","","","","","","Production of the rat type I insulin-like growth factor binding protein by well differentiated H4EIIC3 hepatoma cells: identification, purification and N-terminal amino acid analysis.","Endocinol 1990a","127(2)","789-797","1990","hepatoma","igf","","","","BP assay with PEG and ligand blotting","etal_off","research","copy_off"
"Bachrach LK","Tram T","Goretski P","","","","","","","","Insulin like growth factors and their binding proteins in human thyroid follicular carcinoma cells.","California IGF Meeting Abstracts","","","1991","thyroid","igf","bp","","","Gives nebulous figures for production NOT as per cell. FTC 133 & 236 produce minimal IGF but abundant IGF BPs.","etal_off","research","copy_off"
"Mohan S","Bautista CM","Wergedal J","Baylink D","","","","","","","Isolation of an inhibitory insulin-like growth factor (IGF) binding protein from bone cell-conditioned medium: A potential local regulator of IGF action.","Proc Natl Acad Sci","86","8338-8342","1989","bp","igf","","","","Refs to inhibitory actions of BPs. DSS crosslinking studies. Inhibitory IGF BP found from osteosarcoma cells. Discussion contains good review of inhibitory/stimulatory effects of BPs","etal_off","research","copy_off"
"Minuto F","Barreca A","Del Monte P","Cariola A","","","","","","","Immunoreactive insulin-like growth factor I (IGF-I) and IGF-I-binding protein content in human thyroid tissue.","J Clin Endocrinol Metab","68(3)","621-626","1989","","igf","","","","Norm and MNG studied. Tissue and plasma levels of IGF. Stimulatory effect of TSH is mediated by IGF. IGF levels in MNG>norm. IGF stimulates other GF production - refs. Though no evidence of EGF production.","etal_off","research","copy_off"
"Gelato MC","Gaynes LA","Greenstein","Nissley SP","","","","","","","Heterogeneity of binding subunits of the human 150k insulin-like growth factor binding protein.","J Clin Endocrin Metab","70(4)","879-887","1990","","bp","","","","further evidence for 150k BP made up of multiple subunits with different affinities for IGFs 1 & 2.","etal_off","research","copy_off"
"Lee CY","Henricks DM","","","","","","","","","Comparisons of various acidic treatments of bovine serum on insulin-like growth factor-I immunoreactivity and binding activity.","J Endocrinol","127","139-148","1990","","methods","","","","No abstract available","etal_off","review","copy_on"
"Conver CA","","","","","","","","","","Potentiation of insulin-like growth factor (IGF) action by IGF bindingprotein-3: Studies of the underlying mechanism.","Endocrinol","130","3191-3199","1992","igf","bp3","","","","","etal_off","research","copy_off"
"Liu F","Powell DR","Hintz RL","","","","","","","","Characterization of insulin-like growth factor binding proteins in human serum from patients with chronic renal failure.","J Clin Endocrinol","70","620-628","1990","","","","","","","etal_off","research","copy_off"
"Drop SLS","","","","","","","","","","On the nomenclature of the insulin-like growth factor binding proteins.","Mol Cell Endocrinol","67","243-244","1989","bp","","","","","Good review","etal_off","review","copy_on"
"Baxter RC","","","","","","","","","","Circulating levels and molecular distribution of the acid-labile subunit of the high molecular weight insulin-like growth factor-binding protein complex.","J Clin Endocrinol Metab","70","1347-1353","1990","method","bp","","","","150kDa BP has 3 subunits. More info on the beta (binding) unit.","etal_off","research","copy_off"
"Brinkman A","Groffen C","Kortleve DJ","van Kessel AG","Drop SLS","","","","","","Isolation and characterisation of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1).","EMBO J","7","2417-2423","1988","bp","receptors","","","","Fetal IGF-BP MW 30kDa, notes on receptor affinities.","etal_off","research","copy_on"
"Blat C","Delbe J","Villaudy J","Chatelain G","Golde A","Harel L","","","","","Inhibitory diffusible factor 45 bifunctional activity.","J Bio Chem","264","12449-1245","1989","","bp","","","","?? inhibitory BP - 45 kDa.","etal_off","research","copy_off"
"Hill DJ","Camacho-Hubner C","Rashid P","Strain AJ","Clemmons DR","","","","","","Insulin-like growth factor (IGF)-binding protein release by human fetal fibroblasts: dependency on cell density and IGF peptides.","J Endocrinol","122","87-98","1989","bp","fibroblast","","","","Exogenous IGF stimulates BP production. Sparse cultures release more IGF than confluent. Insulin and hPL cause IGF release.","etal_off","research","copy_on"
"Martin JL","Baxter RC","","","","","","","","","Insulin-like growth factor-binding protein from human plasma: purification and characterization.","J Biol Chem","261","8754-8760","1986","igf","method","","","","More evidence for 26-22 kDa BP subunits of 150 kDa BP","etal_off","research","copy_on"
"Reeve JG","Payne JA","Bleehen NM","","","","","","","","Production of immunoreactive insulin growth factor-I (IGF-I) and IGF-I binding proteins by human lung tumours.","Br J Cancer","61","727-731","1990","lung","method","","","","Acid/EtOH strip. Commercial RIA (Amersham), immunoradiometric assay, binding protein assay-PAGE with DSS cross-linking.","etal_off","research","copy_off"
"Wang JF","Becks GP","Buckingham KD","Hill DJ","","","","","","","Characterization of insulin-like growth factor binding proteins secreted by isolated sheep thyroid epithelial cells.","J Endocrinol","125","439-448","1990","thyroid","bp","","","","Good intro. Cultures prod IGF - ref. Methods for BP study - Ligand blot, s-200 gel etc. 10^5 cells in a 24 well dish. NB - acid gel chromatography denatures BP 46 & 30 -> V0 assay NOT accurate.","etal_off","research","copy_on"
"Dawson TP","James R","Williams GT","","","","","","","","Silicone Plastinated Pathology specimens and their teaching potential.","J Path","162","265–272","1990","","teaching","","","","Plastination as an alternative to formalin fixation.","etal_off","research","copy_on"
"Wyllie FS","Dawson TP","Bond J et al","","","","","","","","Correlated abnormalities of TGF-ß response and p53 structure/expression in thyroid epithelial cell transformation.","Mol Cell Endocrinol","76","13–21","1991","icc","","","","","ICC & TC paper","etal_off","research","copy_on"
"Bond J","Dawson TP","Wynford-Thomas D","","","","","","","","Effect of Serum Growth Factors and Phorbol Esters on Growth and survival of Human Thyroid Epithelial Cells expressing Mutant ras.","Mol Carcinogenesis","5","129–135","1991","TPA","ras","","","","A cure for cancer !!","etal_off","research","copy_on"
